RNA POLYMERASE III INHIBITOR

Biochem/physiol Actions

Target IC₅₀: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

Reversible: no

Product does not compete with ATP.

Primary Targetactivity against RNA Polymerase III

Cell permeable: yes

General description

A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC₅₀ = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wu, L., et al. 2003. Euk. Cell2, 256.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Preparation Note

Slight warming may be necessary to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)